ER veteran Noah Wyle won best drama actor for his performance as the emergency room’s haunted leader.
“Anybody who is going on shift tonight or coming off shift tonight, thank you for being in that job – this is for you,” he said.
Katherine LaNasa also won best supporting actress.
Pundits had considered the race too close to call, with sci-fi office thriller Severance considered difficult to beat.
A psychological drama set largely in the near-future offices of a shadowy corporation, it had the most nominations of any show this year with 27.
The premise: The “innie” employees of Lumon Industries quite literally leave their outside lives, memories and personalities at the door, thanks to a dystopian new mind-splitting technology.
Its star Britt Lower won best actress and Tramell Tillman won for best supporting actor.
“I AM PAYING”
The Studio – both a love letter to the industry, and a searing send-up of its many hypocrisies, insecurities and moral failings – was named best comedy series.
Rogen, its co-creator, won best actor for his role as a floundering movie executive. The show also claimed writing and directing prizes Sunday.
It had earned nine statuettes last weekend at a separate ceremony for the more technical Emmy categories.