A top-five finish will almost certainly secure a place in Europe’s top club competition next season thanks to the strong performance of English sides in European competitions.
Spurs, though, have struggled to handle the burden of Thursday nights when it comes to their Premier League form.
Ange Postecoglou’s side have won just three times in the 10 league matches that have followed a midweek Europa League fixture.
“It’s been a difficult campaign for sure,” said Spurs captain Son Heung-min.
“But I feel we’ve lost too many games that we should have got stuff out of, and this was one of those games.”
Fulham had to wait until 78 minutes to take the lead when Rodrigo Muniz steered home from Andreas Pereira’s pass.
Ryan Sessegnon then curled in a brilliant second against his former club to secure victory late on.
Spurs remain down in 13th, now 10 points off the top half.
Manchester United are in action later on Sunday when Ruben Amorim’s team visit lowly Leicester.
