Hantavirus is a rare disease in the US, with most cases concentrated in the western states of New Mexico, Arizona, Colorado and Utah. In northern New Mexico, the virus is spread by droppings and urine of deer mice.

The virus is often transmitted through the air when people sweep out sheds or clean closets where mice have been living. It begins with flu-like symptoms and can lead to heart and lung failure, with around 38 per cent to 50 per cent of cases resulting in death.

New Mexico has experienced between one and seven cases annually in recent years, according to health data.

State health inspectors found no particular sign of rodents inside Hackman’s home but did detect rodent activity in structures outside the house, State Veterinarian Erin Phipps told reporters.

Hackman and Arakawa, a pianist, called Santa Fe home since the 1980s and were active in the city’s art community and culinary scene. In recent years, the couple were seen less often in town as his health deteriorated. They lived a very private life before their deaths, Mendoza said.

A caretaker at their gated community discovered the couple dead. Sheriff’s deputies found Hackman in the kitchen. Arakawa and a dog were found in a bathroom.

Both Hackman and Arakawa appeared to have suddenly fallen to the floor and neither showed signs of blunt force trauma.

Arakawa had picked up one of her dogs in a crate on Feb 9 from a Santa Fe veterinarian, which may explain why the animal was found dead in the crate in the couple’s home on Feb 26, Mendoza said. Phipps said the dog may have died of starvation.

Hackman, a former Marine known for his raspy voice, appeared in more than 80 films, as well as on television and the stage during a lengthy career that started in the early 1960s.

He earned his first Oscar nomination for his breakout role as the brother of bank robber Clyde Barrow in 1967’s Bonnie and Clyde. He won an Oscar for best actor in 1972 for his portrayal of detective Popeye Doyle in The French Connection, and in 1993 won an Oscar for best supporting actor for Unforgiven.

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