SNL show is seen as having a liberal bent, but mercilessly mocks both Democratic President Joe Biden and Trump.
It had the Republican tycoon on as the host first in 2004 and again when he was a presidential candidate for the 2016 election, but he has since soured on the show.
Last year, he called it a “bad product, not funny, Fake News” and a “campaign contribution to the Democrats” on his social media platform.
“Harris on SNL tonight is a bit like Trump on Fox & Friends this morning,” said liberal media analyst Brian Stelter.
“Both are home team visits. The difference is that the VP’s appearance will reach a much bigger audience.”
The Trump campaign did not respond immediately to a request for comment but a spokesman was quoted by Fox characterising the appearance as Harris “living out her warped fantasy cosplaying with her elitist friends”.
