Ideally, major powers should come together to coordinate their positions and work together to stop conflict, as well as tackle changes like climate change and nuclear proliferation, said the prime minister.
But there is deep suspicion and mistrust between America and China, with each country regarding the other as a strategic threat, he added.
Both countries are taking steps to strengthen their positions, so it will get harder to find common ground, said Mr Wong.
“These are the realities of the world we live in today and the dynamics will be with us for some time; we’re not talking about one or two years and then things will improve, I think we will have to grapple with this perhaps for the next decade or beyond,” he said, adding that Singapore will find it more difficult to make a living and keep itself safe.
Singaporeans will have different views on global developments, but must consider the larger national interest and take a united position, said the prime minister.
“It is already tough to be a small country for our voice to be heard. It will be even tougher if our voice is diffused and incoherent.”
By speaking with one voice on the world stage, Singapore will be valued as a safe, secure, stable and reliable nation in an uncertain world, he added.